Normalization of RNA-Sequencing Data from Samples with Varying mRNA Levels
نویسندگان
چکیده
منابع مشابه
Normalization of RNA-Sequencing Data from Samples with Varying mRNA Levels
Methods for normalization of RNA-sequencing gene expression data commonly assume equal total expression between compared samples. In contrast, scenarios of global gene expression shifts are many and increasing. Here we compare the performance of three normalization methods when polyA(+) RNA content fluctuates significantly during zebrafish early developmental stages. As a benchmark we have used...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0089158